Pharmacodynamic damamycin belongs rau cov tshuaj tua kab mob aminoglycoside, thiab muaj kev cuam tshuam me me ntawm ntau yam kab mob gram-tsis zoo, xws li escherichia coli, salmonella, shigella, proteus thiab lwm yam. Nws yog rhiab heev rau streptococcus, pneumococcus, staphylococcus epidermidis thiab qee qhov mycoplasma (xws li mycoplasma gallinarum, mycoplasma qaib ntxhw, mycoplasma synovialis, thiab lwm yam). Nws yog feem ntau insensitive rau streptococcus viridis thiab staphylococcus aureus. Nws feem ntau tiv taus pseudomonas aeruginosa thiab treponemas. Cov kab mob hauv plab yog dav resistant rau megamycin, tab sis tsis qhia cross-resistance nrog streptomycin. Lincomycin muaj cov tshuaj tua kab mob zoo tiv thaiv kab mob anaerobic, xws li clostridium, peptococcus, peptostreptococcus, clostridium tetanus, clostridium perfringens thiab feem ntau actinomyces. Lincomycin feem ntau ua rau ntawm 50s subunit ntawm cov kab mob ribosomes, uas cuam tshuam cov protein synthesis los ntawm inhibiting qhov txuas ntxiv ntawm peptide saw.
Pharmacokinetics tsuas yog 7% ntawm lincomycin yog nqus tau tom qab kev tswj hwm sab hauv, tab sis nws tswj tau qhov siab ntawm lub plab zom mov. Cov ntaub so ntswg concentration ntawm cov tshuaj yog qis dua cov ntshav concentration. Nws tsis yooj yim rau nkag mus rau hauv cov kua cerebrospinal lossis qhov muag, thiab qhov sib txuas ntawm cov plasma protein tsis siab. Feem ntau cov tshuaj raug tso tawm los ntawm glomerular filtration hauv lawv daim ntawv qub. Lub bioavailability ntawm lincomycin yog 30% ~ 40% nrog kev nqus tsis zoo hauv kev tswj qhov ncauj. Qhov nqus tau thiab tus nqi ntawm lincomycin tuaj yeem raug txo los ntawm kev pub mis sib xyaw. Cov qaib tau muab 50mg ntawm cov khoom no (kua hauv dej haus) ib kg ntawm lub cev hnyav rau 7 hnub. Thaum lub sij hawm kuaj, cov ntshav lincomycin nce mus txog 0.14 μ g / ml, thaum lub concentration ntawm daguanmycin tsawg heev. Tom qab 7 hnub ntawm kev sim, nws tau tshaj 0.1μg / ml.
1. Ua ke nrog lincomycin, nws tuaj yeem ua kom cov kab mob tua kab mob tiv thaiv mycoplasma thiab nthuav cov kab mob tua kab mob.
2. Kev sib xyaw ua ke ntawm lincomycin thiab tshuaj anticholinesterase tuaj yeem txo qhov ua tau zoo ntawm qhov kawg.
3. Ua ke nrog erythromycin muaj cov nyhuv antagonistic.
Tshuaj tua kab mob. Rau cov kab mob Gram-negative, Gram-positive bacteria thiab mycoplasma kab mob.
Mixed haus: 100g ntawm cov khoom no tov nrog dej 200 ~ 300kg rau npua thiab 50 ~ 100kg rau nqaij qaib rau 3 ~ 5 hnub. Mixed feeding: 100g mix feed 100kg for pigs and 50kg for chickens, siv 5 mus rau 7 hnub.
Sow kev kho mob: Los ntawm 7 hnub ua ntej xa mus rau 7 hnub tom qab xa khoom, 100g ntawm cov khoom no yog tov 100kg, los yog 200kg nrog dej. Piglet kev noj qab haus huv: Ua ntej thiab tom qab weaning thiab chaw zov me nyuam, 100g sib tov 100kg, los yog 200kg dej.
Tsis muaj kev phiv tshwm sim thaum siv raws li kev siv thiab ntau npaum li cas.
