30% Lincomycin Hydrochloride Txhaj

Pharmacodynamic lincomycin belongs rau cov tshuaj tua kab mob lincoamine, yog cov kab mob bacteriostatic, cov kab mob rhiab heev muaj xws li staphylococcus aureus (xws li cov kab mob penicillin-resistant), streptococcus, pneumococcus, bacillus anthracis, erysipelas suis, qee cov mycoplasma (mycoplasma), qhov ntswg, mycoplasmasuis synovialis), leptospirosis thiab kab mob anaerobic (xws li clostridium difficile, clostridium tetanus, clostridium percapsulatus thiab feem ntau actinomyces). Nws feem ntau ua rau ntawm 50s subunit ntawm cov kab mob ribosome, thiab tawm tsam cov kab mob los ntawm inhibiting qhov txuas ntxiv ntawm peptide saw thiab cuam tshuam rau cov protein synthesis.

Kev nqus tau sai sai tom qab txhaj tshuaj intramuscular, nrog rau ib qho kev txhaj tshuaj intramuscular ntawm 11mg / kg hauv npua thiab cov ntshav siab tshaj plaws ntawm 6.25μg / ml. plasma protein binding tus nqi yog 57% - 72%. Nws yog dav faib nyob rau hauv vivo, nrog rau qhov pom meej ntim ntawm 2.8 l / kg hauv npua. Nws yog dav faib nyob rau hauv ntau lub cev kua thiab cov ntaub so ntswg (nrog rau cov pob txha), uas cov concentration ntawm daim siab thiab lub raum yog siab tshaj plaws, thiab cov concentration ntawm cov ntaub so ntswg tshuaj yog ob peb zaug ntau dua li cov ntshav nyob rau tib lub sij hawm. Nws tuaj yeem nkag mus rau hauv cov placenta, tab sis nws tsis yooj yim rau nkag mus rau hauv cov ntshav-hlwb barrier, thiab nws yog ib qho nyuaj rau ncav cuag ib tug zoo concentration ntawm cov tshuaj nyob rau hauv lub cerebrospinal kua thaum o tshwm sim. Nws tuaj yeem muab faib rau cov mis nyuj, thiab cov concentration hauv cov mis nyuj yog tib yam li hauv plasma. Ib feem ntawm cov tshuaj yog metabolized nyob rau hauv daim siab, thiab daim ntawv tshuaj thiab nws cov metabolites raug tso tawm los ntawm cov kua tsib, zis thiab mis nyuj. Kev tso tawm hauv cov quav tuaj yeem ncua sijhawm rau ob peb hnub, yog li nws muaj kev cuam tshuam rau cov kab mob hauv plab hnyuv.