10% Hlau Dextran Txhaj

Pharmacodynamic hlau yog qhov tseem ceeb ntawm hemoglobin thiab myoglobin. Hemoglobin yog lub luag haujlwm tseem ceeb ntawm cov pa oxygen hauv cov qe ntshav liab. Myoglobin yog qhov chaw cov leeg hlwb khaws cov pa oxygen los pab muab rau cov leeg nqaij thaum lub sijhawm ua haujlwm. Feem ntau ntawm cov enzymes thiab yam cuam tshuam rau hauv lub voj voog tricarboxylic acid muaj hlau lossis ua haujlwm tsuas yog muaj hlau. Yog li, ntxiv rau kev ua kom hemoglobin nrawm nrawm, cov tsos mob cuam tshuam nrog cov ntaub so ntswg hlau tsis txaus thiab txo qis kev ua haujlwm ntawm cov enzymes uas muaj hlau, xws li kev loj hlob qeeb, kev coj tus cwj pwm txawv txav, thiab lub cev tsis muaj zog, tuaj yeem kho tau maj mam tom qab siv hlau ntxiv hauv cov tsiaj tsis muaj hlau. Pharmacokinetic hlau rau txhaj tshuaj yog absorbed sai dua li qhov ncauj hlau; Tom qab txhaj tshuaj intramuscular ntawm hlau dextran, cov ntshav siab tau mus txog qhov siab kawg ntawm 24-48 teev, thiab nws cov molecule loj dua. Nws tau nqus los ntawm cov hlab ntsha lymphatic thiab tom qab ntawd hloov mus rau hauv cov ntshav, thiab cov ntshav concentration nce qeeb; Tom qab txhaj tshuaj los yog intramuscular txhaj rau hauv cov ntshav ncig, nws yog phagocytic thiab decomposed rau hauv hlau thiab dextran los ntawm mononuclear phagocytic cell system. Tom qab nqus tau, hlau ions yog oxidized rau ferric ions los ntawm ceruloplasmin hauv cov ntshav, thiab tom qab ntawd khi rau cov hloov pauv receptors, nkag mus rau cov hlwb hauv daim ntawv ntawm pinocytosis rau cov hlwb hematopoietic, los yog tsim nyob rau hauv daim ntawv ntawm ferritin lossis hemosiderin hauv daim siab, spleen, pob txha pob txha thiab lwm yam kab mob mononuclear. Cov protein binding tus nqi yog siab nyob rau hauv hemoglobin, tab sis tsawg nyob rau hauv myoglobin, enzymes thiab hlau-transporting proteins, raws li zoo raws li tsawg nyob rau hauv ferritin los yog hemosiderin.