Pharmacodynamics flufenicol yog cov tshuaj tua kab mob dav dav hauv cov chav kawm amidol, cov kab mob bacteriosuppressor, thiab ua los ntawm kev khi nrog ribosome 50s subunit los tiv thaiv kev sib txuas ntawm cov kab mob proteins. Nws muaj zog tiv thaiv kab mob tiv thaiv ntau yam kab mob gram-positive thiab gram-negative kab mob. Pasteurella hemolyticus, pasteurella multocida thiab actinobacillus suis pleuropneumoniae tau rhiab heev rau flufenicol. Hauv vitro, cov tshuaj tua kab mob ntawm flufenicol tawm tsam ntau cov kab mob zoo sib xws lossis muaj zog dua li sulfenicol, thiab qee cov kab mob uas tiv taus cov aminools vim yog acetylation, xws li escherichia coli thiab klebsiella pneumoniae, tseem tuaj yeem ua rau flufenicol.
Nws yog tsuas yog siv rau cov kab mob ntawm npua, nqaij qaib thiab ntses los ntawm cov kab mob rhiab heev, xws li cov kab mob ua pa ntawm nyuj thiab npua los ntawm pasteurella hemolyticus, pasteurella multocida thiab actinobacillus pleuropneumoniae. typhoid thiab paratyphoid tshwm sim los ntawm salmonella, qaib cholera, qaib dawb kab mob, colibacillosis, thiab lwm yam.; ntses pasteurella, vibrio, staphylococcus aureus, hydroomonas, enteritis thiab lwm yam kab mob tshwm sim los ntawm ntses kab mob septicemia, enteritis, erythroderma thiab sai sai.
1. Macrolides thiab lincosamines muaj tib lub hom phiaj raws li cov khoom no, lawv tau ua ke nrog cov kab mob ribosome 50s subunit, thiab tuaj yeem tsim cov teebmeem antagonistic thaum ua ke.
2. Nws tuaj yeem tiv thaiv cov kab mob bactericidal ntawm penicillins lossis aminoglycosides, tab sis nws tsis tau muaj pov thawj hauv cov tsiaj.
Amidoalcohol tshuaj tua kab mob, rhiab heev rau Pasteurella hemolyticus, Pasteurella multocida thiab actinobacillus pleuropneumoniae, siv rau Pasteurella thiab Escherichia coli kab mob.
Los ntawm cov khoom no. Rau kev tswj hwm sab hauv: 0.1 ~ 0.15g ib 1kg lub cev hnyav rau npua thiab qaib. 2 zaug hauv ib hnub rau 3 mus rau 5 hnub; 50 mus rau 75mg rau ntses. Siv ib zaug ib hnub rau 3 mus rau 5 hnub.
Kev pub mis sib xyaw: Cov khoom no 100g sib tov 200 ~ 300kg, siv tas li rau 3 ~ 5 hnub.
1. Cov khoom no muaj qee yam kev tiv thaiv kab mob thaum siv ntau dua li cov tshuaj pom zoo.
2. Nws muaj fetal toxicity, thiab yuav tsum tau siv ceev faj thaum cev xeeb tub thiab lactating tsiaj nyeg.
1. Lub sij hawm nteg qe yuav tsum tsis txhob siv.
2. Tsiaj txhu muaj kev tiv thaiv kab mob hnyav lossis lub sijhawm txhaj tshuaj tiv thaiv yuav tsum raug txwv.
3. Tsiaj txhu muaj lub raum tsis txaus yuav tsum tau txo kom zoo los yog ncua sij hawm tswj xyuas lub sijhawm.
