Pharmacodynamics flufenicol yog cov tshuaj tua kab mob dav dav.
Ntawm aminools, ib tug bacteriosuppressor, thiab ua los ntawm kev khi nrog ribosome 50s subunit los inhibit synthesis ntawm cov kab mob proteins. Nws muaj zog tiv thaiv kab mob tiv thaiv ntau yam kab mob gram-positive thiab gram-negative kab mob. Pasteurella hemolyticus, pasteurella multocida thiab actinobacillus suis pleuropneumoniae tau rhiab heev rau flufenicol. Hauv vitro, cov tshuaj tua kab mob ntawm flufenicol tawm tsam ntau cov kab mob zoo sib xws lossis muaj zog dua li sulfenicol, thiab qee cov kab mob uas tiv taus cov aminools vim yog acetylation, xws li escherichia coli thiab klebsiella pneumoniae, tseem tuaj yeem ua rau flufenicol.
Nws yog tsuas yog siv rau cov kab mob ntawm npua, nqaij qaib thiab ntses los ntawm cov kab mob rhiab heev, xws li cov kab mob ua pa ntawm nyuj thiab npua los ntawm pasteurella hemolyticus, pasteurella multocida thiab actinobacillus pleuropneumoniae. typhoid thiab paratyphoid tshwm sim los ntawm salmonella, qaib cholera, qaib dawb kab mob, colibacillosis, thiab lwm yam.; ntses pasteurella, vibrio, staphylococcus aureus, hydroomonas, enteritis thiab lwm yam kab mob tshwm sim los ntawm ntses kab mob septicemia, enteritis, erythroderma thiab sai sai.
Pharmacokinetics flufenicol yog absorbed sai sai los ntawm kev tswj hwm sab hauv, thiab kev kho mob tuaj yeem ncav cuag hauv cov ntshav tom qab li 1 teev, thiab cov ntshav siab siab tuaj yeem ncav cuag hauv 1 mus rau 3 teev. Lub bioavailability yog ntau tshaj 80%. Flufenicol yog dav faib nyob rau hauv cov tsiaj thiab muaj peev xwm hla cov ntshav-hlwb barrier. Nws yog excreted tsuas yog nyob rau hauv cov zis nyob rau hauv nws cov thawj daim ntawv thiab nyob rau hauv me me nyob rau hauv cov quav.
1. Macrolides thiab lincoamines muaj tib lub hom phiaj raws li cov khoom no, lawv ua ke nrog cov kab mob ribosome 50s subunit, thiab tuaj yeem tsim cov teebmeem antagonistic thaum ua ke.
2. Nws tuaj yeem tiv thaiv cov kab mob bactericidal ntawm penicillins lossis aminoglycosides, tab sis nws tsis tau muaj pov thawj hauv cov tsiaj.
Amidoalcohol tshuaj tua kab mob, rhiab heev rau Pasteurella hemolyticus, Pasteurella multocida thiab actinobacillus pleuropneumoniae, siv rau Pasteurella thiab Escherichia coli kab mob.
Intramuscular txhaj: ib koob, ib 1kg lub cev hnyav, 0.2ml rau nqaij qaib, 0.15 ~ 0.2ml rau yaj thiab npua, 0.075 ~ 0.1ml rau nees thiab nyuj. Ib zaug txhua 48 teev, ob zaug ua ke. Ntses 0.005 rau 0.01ml ib hnub ib zaug.
1. Cov khoom no muaj qee yam kev tiv thaiv kab mob thaum siv ntau dua li cov tshuaj pom zoo.
2. Nws muaj fetal toxicity, thiab yuav tsum tau siv ceev faj thaum cev xeeb tub thiab lactating tsiaj nyeg.
1. lub sij hawm tso hens yog txwv tsis pub.
2. Cov tsiaj uas tsis muaj zog tiv thaiv kab mob hnyav lossis lub sijhawm txhaj tshuaj yuav tsum raug txwv.
3. Cov tsiaj uas muaj lub raum tsis txaus yuav tsum tau txo kom raug lossis ncua sij hawm tswj xyuas lub sijhawm.
