Pharmacodynamics enrofloxacin yog ib qho dav spectrum bactericidal tshuaj rau cov tsiaj fluoroquinolone. Nws muaj cov txiaj ntsig zoo ntawm escherichia coli, salmonella, klebsiella, brucella, pasteurella, actinobacillus pleuropneumoniae, erysipelas, proteus, serratia marcescens, corynebacterium pyogenes, portococcus septicus, staphylococcus arrhythmia. cuam tshuam rau pseudomonas aeruginosa thiab streptococcus, thiab tsis muaj zog ntawm cov kab mob anaerobic. Nws muaj qhov pom tseeb tom qab antibacterial nyhuv rau cov kab mob rhiab heev. Cov tshuaj tua kab mob ntawm cov khoom no yog txhawm rau tiv thaiv kab mob dna rotation enzyme, cuam tshuam nrog cov kab mob dna replication, transcription thiab kho recombination, cov kab mob tsis tuaj yeem loj hlob thiab rov tsim dua qub thiab tuag.
Pharmacokinetics qhov kev nqus dej ntawm cov khoom no yog nrawm thiab ua tiav, nrog rau bioavailability ntawm 91.9% hauv npua thiab 82% hauv cov nyuj. Nws yog dav faib nyob rau hauv cov tsiaj thiab tuaj yeem nkag mus rau hauv cov ntaub so ntswg thiab cov kua dej hauv lub cev zoo, tshwj tsis yog cov kua cerebrospinal, qhov concentration ntawm cov tshuaj nyob rau hauv yuav luag tag nrho cov ntaub so ntswg yog siab dua li cov ntshav plasma. Lub siab metabolism feem ntau yog tsim ciprofloxacin los ntawm kev tshem tawm ethyl ntawm 7-piperazine nplhaib, ua raws li oxidation thiab glucuronic acid khi. Nws yog tsuas yog tawm los ntawm ob lub raum (los ntawm lub raum tubule secretion thiab glomerular filtration), thiab 15% mus rau 50% yog tawm los ntawm cov zis nyob rau hauv nws thawj daim ntawv. Kev tshem tawm ib nrab-lub neej sib txawv heev hauv ntau hom thiab sib txawv ntawm kev tswj hwm. Kev tshem tawm ib nrab-lub neej tom qab txhaj tshuaj intramuscular yog 5.9 teev hauv nyuj, 9.9 teev hauv nees, 1.5 mus rau 4.5 teev hauv yaj, thiab 4.6 teev hauv npua.
1. Cov khoom no muaj cov nyhuv synergistic thaum siv nrog aminoglycoside lossis broad-spectrum penicillin.
2. Heavy hlau ions xws li ca2+, mg2+, fe3+ thiab al3+ canchelate nrog cov khoom no thiab cuam tshuam rau kev nqus.
3. Thaum ua ke nrog theophylline thiab caffeine, nws tuaj yeem txo qhov kev sib txuas ntawm cov ntshav plasma protein, ua rau muaj qhov txawv txav ntawm theophylline thiab caffeine hauv cov ntshav, thiab txawm tias muaj cov tsos mob lom theophylline.
4. Cov khoom no muaj cov nyhuv inhibiting daim siab tshuaj enzymes, uas yuav txo tau cov clearance tus nqi ntawm cov tshuaj mas metabolized nyob rau hauv daim siab thiab ua rau kom cov ntshav cov tshuaj concentration.
Fluoroquinolone tshuaj tua kab mob. Siv rau cov tsiaj nyeg thiab nqaij qaib cov kab mob thiab kab mob mycoplasma.
Intramuscular txhaj: Ib koob, 0.025ml ib 1kg lub cev hnyav ntawm nyuj, yaj thiab npua; 0.025 ~ 0.05ml rau dev, miv thiab luav. Siv 1 mus rau 2 zaug hauv ib hnub rau 2 mus rau 3 hnub.
1. Cov pob txha mos degeneration hauv cov tsiaj me, cuam tshuam rau pob txha loj hlob thiab ua rau lameness thiab mob.
2. Cov tshuaj tiv thaiv ntawm lub plab zom mov muaj xws li ntuav, tsis qab los noj mov, raws plab thiab sai sai.
3. Cov kab mob ntawm daim tawv nqaij muaj xws li erythema, pruritus, urticaria thiab photosensitivity.
4. Kev ua xua, ataxia, qaug dab peg yog pom hauv dev thiab miv.
1. Nws muaj peev xwm excitatory nyhuv ntawm lub hauv paus system, inducing epileptic qaug dab peg, thiab yuav tsum tau siv nrog ceev faj nyob rau hauv cov dev vwm.
2. Carnivores thiab cov tsiaj uas muaj lub raum tsis zoo yuav tsum tau siv nrog ceev faj, uas qee zaus tuaj yeem ua rau cov zis crystalline.
3. Cov khoom no tsis haum rau cov nees. Kev txhaj tshuaj intramuscular yog ib ntus irritants.
4. Cov khoom no yuav tsum tsis txhob siv rau cov dev ua ntej 8 lub lis piam.
5. Cov tshuaj tiv thaiv kab mob ntawm cov khoom no tau nce thiab yuav tsum tsis txhob siv cov tshuaj subtherapeutic rau lub sijhawm ntev.
